When HPV16 E6/E7-specific CD8+ T cell responses were analyzed, we found that TC-1 tumor-bearing mice vaccinated with TA-CIN formulated with GPI-0100 induced dramatically higher E7-specific CD8+ T cell responses than either TA-CIN or GPI-0100 only (Fig. 1D and S2B Fig.). This evidence concerns the gene CD8A and neoplasm.