After cisplatin treatment, vaccination with TA-CIN alone via intra-tumoral (i.t.)administration induced strong HPV16 E7-specific CD8+ T cell responses and resulted in the complete eradication of the established tumors, although in this study a high amount (50 μg) of TA-CIN and intensive administration schedule (3 vaccinations in 6 days) was used. Here, CD8A is linked to cervical squamous intraepithelial neoplasia.