We analyzed not only the association of individual polymorphisms and breast cancer risk, but also the effects of combinations of functionally related polymorphisms (NFKB1 and NFKBIA; IL-8 and IL-10; and TNF c.-418 and c.-488), menopausal status, histopathological type, and cancer grading. This evidence concerns the gene CXCL8 and breast carcinoma.