We found 6 significant genes in the localization of cell process, 6 genes in cell motility process, 7 genes in cell motion process, 3 genes in rho protein signal transduction process, 3 genes in rho protein signal transduction process, 5 genes in epithelium development process, 8 genes in cell adhesion process, 8 genes in biological adhesion process, 5 genes in locomotory behavior process, 3 genes in cellular defense response process which implicate that T2D may impact cellular function. Here, RHO is linked to type 2 diabetes mellitus.