In the present study, in comparison with the wild typemicroglia, CCR5−/− cells showed lower expression levelsof CD86 and impaired production of IL-6 and IL-12 p40 against in vitro infection with N.caninum, suggesting that CCR5−/− microgliawere unable to trigger neuroprotection or the level of protective immunity requiredto clear parasites from the brain. Here, CCR5 is linked to infection.