α7 and α3β2 nAChRs are the putativetargets for SLUR P-1 and SLUR P-2, respectively[6, 11].Recently, SLURP-1 expression was detected in HT-29 human colorectal adenocarcinoma cellsand the level of endogenous production of SLURP-1 in these cells wasdemonstrated to decrease significantly when the cells are treated with nicotine[17]. Here, SLURP1 is linked to colorectal adenocarcinoma.