Further, Kaplan–Meier analysis revealed that the CRC patients with high TET2 mRNA level in histopathologically unchanged tissues had better overall and DFS outcomes (OS median: 41 months; DFS median: 40 months) than those with low TET2 mRNA levels (OS median: 26.5 months; DFS median: 28 months) (Fig. 5c). This evidence concerns the gene TET2 and colorectal carcinoma.