Examples include the colonic and hepatic tumour overexpressed gene (ch-TOG) [3] and the genes encoding the transforming acidic coiled-coil proteins (TACCs) [4], spindle assembly checkpoint (SAC) proteins Mad2 [5] and Bub1 [6], the Ska kinetochore complex [7], kinesin-8 motors [8,9], and the outer kinetochore protein Ndc80/Hec1 (Highly Expressed in Cancer) [10–12], which are all upregulated in several cancers. Here, C4B is linked to cancer.