Nevertheless, as early as 1944, Alexander Haddow of the Chester Beatty Institute and his collaborators demonstrated that stilboestrol and some of its analogues could be beneficial in the treatment of breast cancer, thus paving the way for what would become the adjuvant chemotherapy of breast cancer.42 Other hormones and their synthetic analogues would later also be used to treat cancer in the organs that they control, such as the adrenal cortical hormones ACTH and cortisone to treat cancer of the lymphocytes (e.g., leukemias).43 The gene discussed is POMC; the disease is breast carcinoma.