We also observed a several-fold increase in mRNA levels of the Notch ligands JAG1 and JAG2 at both 22 and 48 hours post hypoxia induction in the GBM lines JHH-GBM10, JHH-GBM14, 040622 and 040821 (Figure 1C, 1D). This evidence concerns the gene JAG1 and glioblastoma.