Similarly, in human ovarian cancer cell lines with high endogenous cyclin E1, OVCAR3, OVCAR4 and OAW28 (Supplementary Fig. 1a), a single low dose of dinaciclib significantly reduced the number of cisplatin-surviving colonies (Fig. 6d, Supplementary Fig. 5c), whereas in SKOV3 cells with high endogenous ERBB2 and low cyclin E1 (Supplementary Fig. 1a), dinaciclib had no added effect on chemosensitivity. The gene discussed is CCNE1; the disease is ovarian cancer.