CCNE1 and ovarian carcinoma: Similarly, in human ovarian cancer cell lines with high endogenous cyclin E1, OVCAR3, OVCAR4 and OAW28 (Supplementary Fig. 1a), a single low dose of dinaciclib significantly reduced the number of cisplatin-surviving colonies (Fig. 6d, Supplementary Fig. 5c), whereas in SKOV3 cells with high endogenous ERBB2 and low cyclin E1 (Supplementary Fig. 1a), dinaciclib had no added effect on chemosensitivity.