The ability of iNOP-7-PLK1 siRNA to reduce NSCLC tumor growth in vivo was further illustrated in a mouse model of experimental metastases, where H1299-Luc NSCLC cells were injected systemically (tail vein) into mice leading to the colonization and growth of NSCLC cells in the lungs and other sites of the body (i.e. lymph nodes). Here, PLK1 is linked to neoplasm.