Longitudinal changes in an asymptomatic MSTD mutation carrier showed that whole brain volume (WBV) changes were −0.47%/year in the first 2 years of assessment and −1.83%/year in the following 5 years, indicating an acceleration of the rate of brain atrophy and suggesting the approaching threshold of a clinically recognizable symptomatology [150]. This evidence concerns the gene MAPT and Brain atrophy.