CHMP2B and amyotrophic lateral sclerosis: This subunit of the ESCRT-III protein complex, involved in intraluminal vesicle (ILV) sorting in MVBs, is important in successful autophagic degradation, as CHMP2B mutations, found in a subset of FTD and amyotrophic later sclerosis (ALS) patients, compromise lysosomal degradation of AV cargo [40].