Because a similar role in cellular signaling control has recently also been ascribed to certain autophagy regulators and autophagosomal membranes [84, 85], it seems plausible to assume that anomalies in endolysosomal–autophagic system, common to both NPC and AD, may at least in part explain the aberrant activity of enzymes regulating tau phosphorylation. The gene discussed is MAPT; the disease is Alzheimer disease.