Mutations in SFTPC were found only in the IPF cohort and included the common disease-causing allele p.I73T as well as two other mutations (p.L110R and p.A112T) previously identified in children with ILD but not in adults with IPF (table 3, unpublished data A Hamvas and L M Nogee, 2014).15 None of the SFTPC mutations was present in individuals with COPD or in the ESP database. This evidence concerns the gene SFTPC and chronic obstructive pulmonary disease.