ADAM17 and infection: In an infant rat PM model, several molecules with different inhibitory profiles (MMPs or TNF-α converting enzyme (TACE)) were able to reduce animal mortality [19],[21], cortical necrosis [15],[17]-[19],[21], hippocampal apoptosis [17],[21], BBB disruption [19], cyto-/chemokine release [21], and also post-infection sequelae [17]-[19].