Importantly, TGFBR2 is a metastatic suppressor in CRC: previous research showed that downregulation of TGFBR2 increased migration and invasion of HT29 cells in vitro [27] whereas evidences from in vivo studies suggested that loss of TGFBR2 contributed to colon cancer development and metastasis in cooperation with mutant K-ras or in the context of PTEN loss [40,41]. This evidence concerns the gene KRAS and colonic neoplasm.