First, siRNA targeting TGFBR2 was transiently transfected into SW480 cells and as shown in Figure 5A, expression of TGFBR2 was markedly suppressed and this resulted in enhanced migration and invasion in SW480 cells (Figure 5B, P < 0.01), suggesting the involvement of TGFBR2 in CRC cell metastasis and invasion. Here, TGFBR2 is linked to colorectal carcinoma.