Using high-throughput genomic technology, a genome-wide association study (GWAS) has revealed one intronic single nucleotide polymorphism (SNP) from the DEPDC5 (Dishevelled, Egl-10 and Pleckstrin domain-containing 5) region that was strongly associated with the risk of HCC progression in Japanese patients chronically infected with HCV [16]. The gene discussed is DEPDC5; the disease is hepatocellular carcinoma.