NR4A1 and breast cancer: Although the reason that the multigene assays are actively utilized for ER-positive disease has not been fully clarified, authors of meta-analyses of various multigene breast cancer signatures concluded that the prognostic values of the signatures are comparable when evaluated in hormone receptor–positive breast cancers, presumably due to the fact that the proliferation modules within these diverse gene signatures are a common driving force behind their overall prognostic performance [25],[26].