To increase tissue substrate (GlcCer and GlcSph) load and to accelerate disease phenotypes in the mouse model of Gaucher disease, mice from the GCStg3 founder line were bred into the GCase point mutated 9V/9V and 9V/null mice that had normal WT GCS (Ugcg+/+). This evidence concerns the gene UGCG and Gaucher disease.