However, since the involvement of PLEKHG7 and ERBB4 could not be confirmed in the validation set and conflicting data have been reported for OXSR1, BSG, NT5E, and NETO2 in other tumor types (summarized in Table 4), we consider these as less probable candidate tumor suppressor genes in osteosarcoma tumorigenesis. The gene discussed is ERBB4; the disease is osteosarcoma.