Based on their frequent aberrant copy number in our osteosarcoma set, the frequent under-, respectively, overexpression in our osteosarcoma set as well as in a validation set, and their documented involvement in other tumor types, we identified CMTM8, and possibly also ODZ3, as a new candidate tumor suppressor gene, and GPR177 as a new candidate oncogene involved in osteosarcoma tumorigenesis. Here, CMTM8 is linked to osteosarcoma.