The increased PI(4,5)P2 binding of the kinase-dead G161V-AKT2 mutant (Figure 4D) was reminiscent of the most common somatic AKT mutation in human cancer (E17K-AKT1) which localizes to the plasma membrane due to increased affinity for the constitutive plasma membrane lipid PI(4,5)P2 (Carpten et al., 2007; Landgraf et al., 2008). The gene discussed is AKT1; the disease is cancer.