Among the main factors that contribute to remodeling after MI or ovariectomy (OVX), the renin angiotensin system (RAS) seems to play an essential role, acting on collagen synthesis and degradation via activation of the AT1 receptor of angiotensin II (AngII), [8] as well as increasing reactive oxygen species (ROS) production, creating an oxidative stress environment. The gene discussed is AGT; the disease is myocardial infarction.