This was confirmed by animal assays which showed that: 1) a CDK2-AP1 silenced group was more tumorigenic and had a faster growth rate of tumor than the controls; 2) higher expression of CDK2 and CyclinD1 was seen, accompanied by a higher ratio of bcl2/bax in the CDK2-AP1 silenced group than in the control group. The gene discussed is CCND1; the disease is neoplasm.