Our data indicate that NFATc2 signaling is an essential mediator of myeloid cell responses to microbial antigens, consistent with previous reports that dectin-1 signaling in DCs is essential for effective host protection against fungal infections (4), and suggesting a broader role for NFAT signaling in immune regulation than that originally described in T cells more than two decades ago (14,48). This evidence concerns the gene NFATC2 and fungal infectious disease.