CCL2 and neoplasm: We also observed that NFATc2 directly regulated a large group of chemokine genes with broad biological effects; CCL1 has been shown to influence regulatory T-cell function (53), CCL2 directs DCs to the tumor bed to promote killing of malignant cells (54), CCL3 contributes to the initiation of chronic myeloid leukemia (55) and CCL4 suppresses autoimmune destruction of islet β-cells (56).