ATP2A2 and epilepsy: For instance, we found that the ATP2A2 gene, encoding one of the sarco/endoplasmic reticulum Ca(2+)-ATPases (SERCA) (which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells), ranked very highly in the evolutionary intolerance score in adult brain tissue (EvoTol percentile score = 5.7) and was associated with epilepsy by UniProt (Supplementary Table S3).