CAV1 and pulmonary arterial hypertension: Cav1 is widely expressed, and genetic loss of Cav1 in mice results in almost complete loss of caveolae in vivo, associated with altered lipid metabolism, pulmonary hypertension and fibrosis, nitric oxide (NO) dysfunction, and cardiac abnormalities (Drab et al, 2001; Razani et al, 2001a).