In addition, by reducing p-cofilin via ITGα2 silencing and by treatment with ROCK1 inhibitor it has been further proved that the pro-migratory activity of EZH2 in CRC takes part in regulatory mechanisms that control cell-shape and cell-protrusions and that phosphorylation of cofilin is crucial for cancer cell-migration. This evidence concerns the gene ITGA2 and colorectal carcinoma.