HSPB1 and spinocerebellar ataxia type 17: It has been reported that mutant TBP enhanced the interaction of TBP with the general transcription factor IIB and transcription factor nuclear factor Y (NFY), thereby inhibiting their associations with the promoters of the Hsp25, Hsp70 and/or HspA5 genes in SCA17 mouse models [27], [28].