TP53 and breast cancer: Fig. 2 showed that the expression level of p53 and bcl2, respectively, increased and decreased in both cells treated with lupeol, lupeol epoxide, lutein, lutein epoxide, eugenol and eugenol epoxide for 6 and 12 h incubation compared to untreated cells. The expression level of p53 and bcl2 in both breast cancer cells treated with these compounds was time dependent. Fig. 3 indicated that the relative expression of bax was increased in cells treated with all pure compounds for 6 and 12 h incubation compared to untreated cells.