Although HLA-B15-DR4 boasts an important association with hyperimmune manifestations [43], insulin-allergic subjects exhibit a greater prevalence of HLA-Bw44, HLA-DR7, and HLA-A2 and their combinations, with a RR of 20.6 for developing an allergy/immune reaction to insulin [44] and the presence of a specific immune response gene for insulin [43]. This evidence concerns the gene INS and allergic disease.