Although no associations were found between the clinicopathological factors of gender, age, pT stage, or pN stage and the CLCA2 protein expression status, the frequency of cancers showing poorer differentiation (G3) was higher in the CLCA2-negative cancers than in the CLCA2-positive cancers (P < 0.0001, chi-square test) (Table 4). The gene discussed is CLCA2; the disease is cancer.