NEUROD6 and Alzheimer disease: Notably, the expression of neuronal differentiation 6 (NeuroD6), a brain-specific basic helix-loop-helix (bHLH) transcription factor [23], is greatly reduced at fold changes 0.095 for EMU and 0.159 for UKY in AD brains (q = 0.0023  for EMU and 0.0006 for UKY) (Table 1, italicized).