APOA5 and Insulin resistance: Given the effect of ApoA5 knockdown in ectopic lipid content in liver and muscle and the strong relationship between ectopic lipid content and insulin resistance in these tissues (15, 18, 19), we performed hyperinsulinemic-euglycemic clamp studies combined with 3H/14C-labeled glucose infusions in order to determine whether the reduced ectopic lipid content seen in ApoA5 ASO-treated mice was associated with protection from lipid-induced insulin resistance.