The recent association of caspase-11 with a noncanonical inflammasome, combined with the knowledge that previous studies reporting a role for caspase-1 in colitis models of intestinal inflammation were likely carried out on Casp1,Casp11 double-knockout mice (14–16), led us to investigate the involvement of caspase-11 in intestinal inflammation. The gene discussed is CASP1; the disease is colitis.