INS and hyperinsulinism: We have also confirmed hyperglycemia and hyperinsulinemia in the obese Zucker model comparative to lean controls, with plasma glucose and insulin concentrations of 271.2 ± 36.2 mg/dL versus 110.4 ± 18.2 mg/dL (p < 0.005) and 11.8 ± 0.3 μUnits/mL versus 3.8 ± 0.7 μUnits/mL (p < 0.001), respectively (Figure 1).