Cytotoxicity of ellipticine corresponded to the amounts of ellipticine-DNA adducts formed in the specific cancer cells and depended on expression levels of CYP enzymes metabolizing ellipticine (CYP1A1, 1B1, and 3A4) and/or cytochrome b5 in these cells [36,41,43,44,45,46]. This evidence concerns the gene CYB5A and cancer.