AKAP6 and cardiac hypertrophy: Collectively, these data suggest a model in which mAKAP acts as a main organizer of cAMP, Ca2+ and MAPK signaling and works to regulate cardiac hypertrophy, and thus with the established importance of mAKAP in cardiac hypertrophy, it is now critical to delineate the functional significance of known mAKAP SNPs and screen for additional mAKAP polymorphisms.