We investigated the results (Figure 6) that suggest that induction of TLR8 by 3M002 in CRC cancer cell lines can reduce the secretion of IL-6 and IL-8 [38], however, the cellular mechanisms associated with the inhibition of metastasis particularly driven by 3M002 remain to be elucidated. The gene discussed is TLR8; the disease is colorectal carcinoma.