C3 and systemic lupus erythematosus: Exposure to ES-62 did, however, reduce IgG and C3 deposition in the kidneys (Figure 4B) and modulated the phenotype of the infiltrating cell population, selectively reducing the proportion of CD3+ T cells, Lin− CD127+ innate lymphoid cells (ILCs), and CD11b+ cells (Figure 4C) while increasing the levels of antiinflammatory F4/80highCD11c−CD206+Ly-6G+ M2 macrophages (Figure 4D) (mean ± SEM 2 ± 0.4% of live cells in PBS-treated mice and 5.5 ± 2.5% of live cells in ES-62–treated mice) associated with protection, which appear to be depleted in SLE 30.