Moreover, in a mouse model of asthma, IL-10–producing B cells induced by the trematode helminth Schistosoma mansoni suppressed disease 69,70, and in addition, B cells from mice infected with the gastrointestinal nematode Heligmosomoides polygyrus protected against the development of both allergic airway inflammation and autoimmune inflammation in an experimental model of autoimmune encephalomyelitis 71. This evidence concerns the gene IL10 and asthma.