A recent study in Polish population revealed carriers of the homozygous CC of 1181 OPG gene were shown to have normal coronary arteries more frequently when compared with heterozygotes for CG or homozygotes for GG, but not 209 C/T and 245 C/T C polymorphisms.36 However, another study in Korean population failed to show a significant association between OPG and RANK polymorphisms and acute coronary syndrome occurrence.37 In Chinese EH patients, we found that the polymorphism at 1181 G > C locus is closely associated with the risk and the severity of for LVH development. This evidence concerns the gene TNFRSF11A and acute coronary syndrome.