Genetically, the 163 A > G (rs3102735) is located in promoter, 1181 G > C (rs2073618) located in exon I, and 245 T > G (rs3134070) is located in promoter of the OPG (chromosomal location 8q24).35 Of all genetic variants, the polymorphism at 1181 G > C locus seems to be more associated with cardiovascular disease than the others. Here, TNFRSF11B is linked to cardiovascular disorder.