In order to investigate the specificity of the four novel proteins identified as selectively expressed in islets of Langerhans (CFC1, FAM159B, RBPJL and RGS9), further analysis was performed on a TMA containing pancreatic tissues from seven T1D subjects, seven T2D subjects as well as 26 non-diabetic subjects (Fig. 3). The gene discussed is SHISAL2B; the disease is type 2 diabetes mellitus.