KALRN and schizophrenia: Intriguingly, circabidian (48 hr) or free-running rhythms in locomotor activity reminiscent of the behavioral patterns we detected in Slc6a3−/− or Meth-treated mice (Figures 4F, 7C,F, 9B) have been observed in schizophrenic subjects (Wirz-Justice et al., 2001; Wulff et al., 2012), suggesting that DUO dysregulation underlies the rest-activity aberrations associated with schizophrenia.