The importance of particularly the let-7 family of miRNAs in suppressing HMGA2 is evident by the fact that multiple let-7 binding sites are in the 3’UTR of HMGA2. The correlation between let-7 down-regulation and HMGA2 over-expression in NETs previously shown by Rahmann et al. [60] suggests that the basis for metastasis is founded very early in the carcinogenesis of NETs and lasts until the tumor actually metastasizes. Here, HMGA2 is linked to neoplasm.