In breast cancers, inhibition of MAPK suppresses invasion and metastasis in part by increasing let-7 expression, which leads to suppression of the let-7 targets High-mobility group AT-hook 2 (HMGA2) and BTB-and CNC homology 1 leucine zipper transcription factor (BACH1) [13,14]. This evidence concerns the gene HMGA2 and breast carcinoma.