Others found the DBC-1 (deleted in breast cancer gene 1) tumor suppressor inhibits SIRT1-mediated p53 deacetylation [111,112], while a positive activator of SIRT1 named AROS promotes cell survival in the face of DNA damage by enhancing SIRT1-mediated deacetylation and inactivation of p53 [113]. The gene discussed is SIRT1; the disease is neoplasm.