Similar to our observations in adults, serum expression of MMP-1, -2, -13, TIMP-2, HA, and PIIIP was unchanged between pediatric CF patients with a FEV1 (S4Table) or VC (S5 Table) below and above 80%, or a ratio of FEV1/VC (S6 Table) above and below 70%. This evidence concerns the gene TIMP2 and cystic fibrosis.