NFKB1 and cystic fibrosis: Further, basic research corroborates the etiologic role of MMP-8 and MMP-9 for pulmonary inflammation in CF [38], [39] and it was demonstrated that peroxisome proliferator-activated receptor (PPARγ) agonists can inhibit the inflammatory response in CF cell lines and CF mice at least in part by the attenuation of NF-κB-driven processes such as MMP-9 production [38].