NQO1 and breast cancer: Our results are supported by those of Fagerholm’s [13], who demonstrated that rs1800566 TT genotype was a poor prognostic and predictive factor in the treatment of breast cancer patients, probably due to the C to T substitution, which causes a Pro to Ser change at the residue 187, resulting in low level of NQO1 activity and impaired detoxification of ROS.