Mechanical impairment of peripapillary circulation also results in retinal ischemia and release of vascular endothelial growth factor (VEGF), which may trigger the development of choroidal neovascularization (CNV) and/or polypoidal choroidal vasculopathy (PCV), leading to subretinal haemorrhage [3, 6–10]. The gene discussed is VEGFA; the disease is choroidal neovascularization.