The peripheric portion of the tumor presented a different profile: 5/84 CpG sites were aberrantly methylated, from which 2 sites were shared with the center portion, that is, MSH3 and MLH1, and 3 sites were exclusively methylated in the tumor periphery, that is, MSH6, MGMT, and APC (Table 2). Here, MSH3 is linked to neoplasm.