However, upon observing development of cystoid macular edema after intravitreal bevacizumab injection in a premature infant and finding no correlation between stage of ROP and cystoid macular edema, Dubis et al. proposed that mechanical traction and neurohumoral factors other than VEGF could have a role in the development of cystoid macular edema in premature infants [14]. This evidence concerns the gene VEGFA and Cystoid macular dystrophy.