Furthermore, our results suggest that the MTHFD1 1958GA genotype is associated with maternal risk for DS and also that there is no significant association among MTR c.2756A>G (rs1805087), TC2 c.776C>G (rs1801198), and CβS c.844ins68 polymorphisms and maternal risk for DS. This evidence concerns the gene MTHFD1 and Dravet syndrome.